Takayoshi Suzuki
The University of Osaka
Professor
Japan
B.S., 1995, The University of Tokyo; Ph.D., 2005, The University of Tokyo (advisor: Tomohiko Ohwada); Assistant Professor, 2003-2009, Nagoya City University; Visiting Scientist, 2007-2008, The Scripps Research Institute (advisor: M. G. Finn); Lecturer, 2009-2011, Nagoya City University; Professor, 2011-2019, Kyoto Prefectural University of Medicine; Professor, 2019-present, The University of Osaka
A Novel PROTAC G9a/GLP Degrader that Inhibits, Similar to G9a siRNA, the Migration of MCF-7 Breast-Cancer Cells without Affecting Proliferation. Mukherjee, A. et al. J. Med. Chem., 68, 18258-18271 (2025)
G9a/GLP Modulators: Inhibitors to Degraders. Mukherjee, A. et al. J. Med. Chem., 68, 953-985 (2025)
Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice. Li, H. et al. Neuron, 112, 786-804.e8 (2024).
Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. Itoh, Y. et al. J. Med. Chem., 66, 15171-15188 (2023)
Evolution of Slow-Binding Inhibitors Targeting Histone Deacetylase Isoforms. Mukherjee, A. et al. J. Med. Chem., 66, 11672-11700 (2023)
Recent progress on small molecules targeting epigenetic complexes. Itoh, Y. et al. Curr. Opin. Chem. Biol., 67, 102130 (2022)
Cross-Species Chromatin Interactomes Drive Heterochromatin, Enhancer, and Transcriptional Rewiring in Epstein-Barr Virus Positive Gastric Adenocarcinoma. Okabe, A. et al. Nat. Genet., 52, 919-930 (2020)
A metabolic pathway-oriented screening targeting S-adenosyl-L-methionine reveals the epigenetic remodeling activities of naturally occurring catechols. Ogihara, S. et al. J. Am. Chem. Soc., 142, 21-26 (2020)
My Lab is advancing chemical biology and medicinal chemistry research with a focus on organic chemistry. I believe that the most fascinating aspect of organic chemistry is the creation of molecules with new functions. Organic chemistry has the power to make the impossible possible. In our laboratory, we are using the power of organic chemistry to challenge life science research. We create biologically active molecules (future molecules) with new functions that have never existed before, and use them in research to elucidate life phenomena (chemical biology) and in attempts to apply them to pharmaceuticals (medicinal chemistry research).
