YongXiang Chen
Tsinghua University
Associate Professor
China
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Protein and peptide chemistry, Protein modification, Phosphorus chemical biology, Biomedical application
B.S., 2002, Hunan University; Ph.D., 2007, Tsinghua University (advisor: Yan-Mei Li); Postdoctoral Training, 2007-2011, Max-Planck Institute of Molecular Physiology (advisor: Herbert Waldmann); Associate Professor, 2011-2016, Tsinghua University; Associate Professor (Tenure-track), 2016-2023, Tsinghua University; Associate Professor (Tenured), 2023-present, Tsinghua University
Zhou, Y.; Chang, R.; Yang, Z.; Guo, Q.; Wang, M.; Jia, B.; Li, B.; Deng, B. D.; Ren, Y.; Zhu, H.; Wang, X.; Wang, Q.; Wen, H.; Zhang, H.; Yu, J.*; Chen, Y.-X.*; Liu, K.*, Dynamic peptide nanoframework-guided protein coassembly: advancing adhesion performance with hierarchical structures. Journal of the American Chemical Society, 2025, 147, 2335-2349.
Duan, H.-Z.; Hu, C.; Li, Y.-L.; Wang, S.-H.; Xia, Y.; Liu, X.*; Wang, J.*; Chen, Y.-X.*, Genetically Encoded Phosphine Ligand for Metalloprotein Design. Journal of the American Chemical Society 2022, 14 (50), 22831-22837
Chang, R.; Chen, J.-L.; Zhang, G.-Y.; Li, Y.; Duan, H.-Z.; Luo, S.-Z.; Chen, Y.-X.*, Intrinsically Disordered Protein Condensate-Modified Surface for Mitigation of Biofouling and Foreign Body Response. Journal of the American Chemical Society 2022, 144 (27), 12147-12157
Chang, R.; Liu, Y.-J.; Zhang, Y.-L.; Zhang, S.-Y.; Han, B.-B.; Chen, F.*; Chen, Y.-X.*, Phosphorylated and Phosphonated Low-Complexity Protein Segments for Biomimetic Mineralization and Repair of Tooth Enamel. Advanced Science 2022, 2103829
Hu, J.; Sun, X.-M.; Su, J.-Y.; Zhao, Y.-F.; Chen, Y.-X.*, Different phosphorylation and farnesylation patterns tune Rnd3-14-3-3 interaction in distinct mechanisms. Chemical Science 2021, 12 (12), 4432-4442
Li, F.-Y.; Zhang, Z.-F.; Voss, S.; Wu, Y.-W.; Zhao, Y.-F.; Li, Y.-M.; Chen, Y.-X.*, Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide. Chemical Science 2020, 11 (3), 826-832
Wu, J.-J.; Chen, F.-Y.; Han, B.-B.; Zhang, H.-Q.; Zhao, L.; Zhang, Z.-R.; Li, J.-J.; Zhang, B.-D.; Zhang, Y.-N.; Yue, Y.-X.; Hu, H.-G.; Li, W.-H.; Zhang, B.*; Chen, Y.-X.*; Guo, D.-S.*; Li, Y.-M.*, CASTING: A Potent Supramolecular Strategy to Cytosolically Deliver STING Agonist for Cancer Immunotherapy and SARS-CoV-2 Vaccination. CCS Chemistry 2023, 5 (4), 885-901
Zhao, T.; Yang X.; Duan, G; Chen, J.; He, K; Chen, Y.-X.*; Luo, S.-Z.*, Phosphorylation-regulated phase separation of syndecan-4 and syntenin promotes the biogenesis of exosomes. Cell Proliferation 2024, e13645
My lab offers the training of protein and peptide synthesis and characterization training, molecular cloning & protein expression, cell culture & imaging, animal model, etc.
