Fumika Yakushiji
Nagasaki University
Professor
Japan
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Chemical epigenetics, Chemical probes, Synthetic organic chemistry, Peptide, Small molecules
B.S., 2004, Tokushima University; Ph.D., 2009, Tokushima University (advisor: Kozo Shishido); Assistant Professor, 2009–2016, Tokyo University of Pharmacy and Life Sciences; Visiting Scientist (Postdoctoral Training), 2013–2015, Broad Institute of Harvard and MIT (advisor: Stuart L. Schreiber); Senior Lecturer, 2016–2021, Hokkaido University; Associate Professor, 2021–2024, Hokkaido University; Professor, 2024–present, Nagasaki University.
Structure-guided design and development of cyclic peptide allosteric activators of Polycomb Repressive Complex 2. BioRxiv2025, DOI: https://doi.org/10.1101/2025.06.26.661818.
Total synthesis of acaulide and acaulone A. Org. Lett. 2020, 22, 5545–5549.
Synthetic Modifications of Histones and Their Functional Evaluation. Chem. Asian J. 2022, 17, e202200197.
My lab can offer natural products and peptide-based chemistry driven chemical biology. Our research is advancing with the goal of developing original chemical probes and gaining new biological insights related to epigenetics (histone modifications) and biological phase separation.
