Ganesh Pandian Namasivayam
Kyoto University
Principal Investigator
Japan
Bio-inspired therapeutics, Transcription therapy, Epigenetics
NAMASIVAYAM Ganesh Pandian started his research at the Indian Institute of Technology -Madras and moved to Niigata University with a Japanese Government scholarship to complete his Ph.D. (Biosciences) in 2009. He relocated to Kyoto University as a research associate in 2010 after serving as a visiting scientific advisor in the Ushiki patent office. Ganesh is now a Principal Investigator at Kyoto University Institute for Advanced Study and Head of IN-CBI, an Indo-Japan Government Initiative, an Adjunct PI at University of Zurich, AO Research Institute (Switzerland), Rutgers University (USA), Visiting Professor at IIT-Roorkee, and a scientific advisor in ReguGene Co. Ltd.
Targeted Delivery of Bezafibrate via Silica Nanoparticles Restores Mitochondrial Function and Reduces Oxidative Stress in Insulin-Resistant Cells. A. Jannat, et al., Ganesh N. Pandian, (2025) ACS Appl. Bio Mater., https://doi.org/10.1021/acsabm.5c00721
Nucleic acid-based small molecules as targeted transcription therapeutics for immunoregulation D. Bai et al., Ganesh N. Pandian, (2024) Allergy, 79, 843-860.
Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation. T. Hidaka et al., Ganesh N. Pandian, H. Sugiyama. (2022) CELL Chem. Biol. 29 (4), 690-695.
Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model. M. Malinee, Ganesh N. Pandian, H. Sugiyama. (2022) CELL Chem. Biol. 29, 463-475.
Structural color-enhanced microfluidics. D. Qin, A. H. Gibbons, M.M. Ito, S. S. Parimalam, H. Jiang, H.E. Karahan, B. Ghalei, Ganesh N. Pandian, and E. Sivaniah. (2022) Nat. Comm. 13, e228.
Chemical probe-based Nanopore Sequencing to Selectively Assess the RNA modifications. S. Ramasamy et al., Ganesh N. Pandian. (2022), ACS Chem. Biol., 17, 2704-2709.
A near-infrared fluorogenic pyrrole–imidazole polyamide probe for live-cell imaging of telomeres. Y. Tsubono, Ganesh N. Pandian, et al., (2020) J. Am. Chem. Soc. 142, 41, 17356–17363.
Creation of a synthetic ligand for mitochondrial DNA sequence recognition and promoter specific transcription suppression. T. Hidaka, Ganesh N Pandian et al., (2017) J. Am. Chem. Soc. 139, 8444-8447.
The Namasivayam Group at Kyoto University (WPI-iCeMS) focuses on chemical biology and nanotechnology to develop programmable transcription therapies and advanced diagnostic platforms. The lab pioneers Pyrrole-Imidazole Polyamide (PIP)–based transcription factors, bezafibrate-loaded nanoscaffolds, and DNA-origami nanopores for molecular and transcriptome sequencing. With cutting-edge facilities for super-resolution imaging, nanopore sequencing, and microfluidic fabrication, the group offers strong training in epigenetic modulation, mitochondrial reprogramming, and single-molecule analysis. Through its international IN-CBI (Intelligent ChemBioInformatics) initiative, the lab connects Japan and India to promote collaborative research and nurture young scientists in precision medicine, cellular rejuvenation, and sustainable biotechnology.
