Govindaraju Thimmaiah
JNCASR
Professor
India
Neurodegenerative diseases, Redox biology, Ferroptosis and cuproptosis, Neuroinflammation, Theranostics (diagnostic therapy)
B.Sc. (1998) and M.Sc (2000), Bangalore University; Ph.D., 2006, National Chemical Laboratory and University of Pune (Advisor: Krishna N. Ganesh); Postdoctoral Training, 2005-2006, University of Wisconsin-Madison (Advisors: Nicholas L. Abbott and Ronald T. Raines); Max Planck Institute of Molecular Physiology (Advisor: Herbert Waldmann), Assistant Professor, 2008-2014, and Associate Professor, 2008-2014 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR); Professor, 2020-present, JNCASR.
M. Ramesh and T. Govindaraju, miR-7a-Klf4 axis as a regulator and therapeutic target of neuroinflammation and ferroptosis in Alzheimer's disease, NAR. Mol. Med. 2025, 2, ugaf022. DOI: 10.1093/narmme/ugaf022
M. Ramesh, C. Balachandra, A. Kumar, S. Samanta and T. Govindaraju, Combating multiple aetiologies of Alzheimer’s disease to rescue behavioural deficits, Chem. Sci. 2025, 16, 12476-12492. https://doi.org/10.1039/D4SC08585J
S. Sain, M. Ramesh, K. K. Bhagavath, T. Govindaraju, Enzyme-induced liquid-to-solid phase transition of mitochondria-targeted AIEgen in cancer theranostics, Mater. Horiz. 2025, 12, 3017-3023.
S. Mandal, M Ramesh, T Govindaraju, Strategic mutations in designer native peptides combat NLRP3 inflammasome activation in neurodegenerative disorders, J. Med. Chem. 2025, 68, 2890-2902.
H. Moorthy, M. Ramesh, D. Padhi, P. Baruah, and T. Govindaraju, Polycatechols inhibit ferroptosis and modulate tau liquid–liquid phase separation to mitigate Alzheimer's disease, Mater. Horiz. 2024, 11, 3082-3089.
D. Padhi, P. Baruah, M. Ramesh, H. Moorthy, T. Govindaraju, Hybrid molecules synergistically mitigate ferroptosis and amyloid-associated toxicities in Alzheimer's disease, Redox Biol. 2024, 71, 103119.
P. Baruah, H. Moorthy, M. Ramesh, D. Padhi, and T. Govindaraju, A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease, Chem. Sci. 2023, 14, 9427-9438.
S. Pratihar, R. Venkatesh, M. N. Mattath, T. Govindaraju, Identification and detection of conserved G-quadruplex in monkeypox virus using conformation specific fluorogenic probe. Chem. Commun., 2024, 60, 13004-13007.
Our laboratory offers excellent facilities for chemical biology research in the field of neuroscience, with a specific focus on neurodegenerative diseases. Our areas of emphasis include redox biology, ferroptosis, cuproptosis, neuroinflammation, and Alzheimer’s disease. We aim to investigate multifactorial disease mechanisms and develop innovative tools and platforms for detection and treatment. Our group is also actively engaged in research on non-canonical DNA structures, particularly G-quadruplexes (G4), for targeted diagnostics and therapeutics.
