Dan Yang
Westlake University
Chair Professor of Chemical Biology
China
-
Disease mechanism, Fluorescent sensors, Molecular imaging, Proteomics, Drug development
B.Sc., 1985, Fudan University; M.A., 1987, Columbia University (advisor: Ronald Breslow); Ph.D., 1991, Princeton University (advisor: Daniel Kahne); Postdoctoral Training, 1991–1993, Harvard University (advisor: Stuart L. Schreiber); Assistant Professor (1993–1999), Associate Professor (1999–2000), Professor (2000–2004), Chair Professor of Chemistry (2005–2021), Morningside Professor in Chemical Biology (2007–2021), The University of Hong Kong; Chair Professor of Chemical Biology (2021–present), Westlake Universit
Y.-S, Li, X.-Y. Bai, D. Yang*. Development and application of cationic Nile blue probes in live-cell super-resolution imaging and specific targeting to mitochondria. ACS Central Sci. 2024, 10, 1221−1230.
L. Chen#, T.-H. Yang#, X. Sun, C. C. L. Wong,* D. Yang*. Protein Tyrosine Amination: Detection, Imaging and Chemoproteomic Profiling with Synthetic Probes. J. Am. Chem. Soc. 2024, 146, 11944−11954.
W. Wang#, N.-K. Wong#, S.-L. Bok, Y. Xu, Y. Guo, L. Xu, M.-L. Zuo, C. M. St. Croix, G.-W. Mao, A. Kapralov, H.Bayir, V. E. Kagan, D. Yang*. Visualizing Cardiolipin In Situ with HKCL-1M, a Highly Selective and Sensitive Fluorescent Probe. J. Am. Chem. Soc. 2023, 145, 11311-11322.
S.-Y. Dai, D. Yang*. A Visible and Near-Infrared Light Activatable Diazo-Coumarin Probe for Fluorogenic Protein Labeling in Living Cells. J. Am. Chem. Soc. 2020, 142, 17156–17166.
F.-F. Shen, S.-Y. Dai, N.-K. Wong, S. Deng, A. S.-T. Wong, D. Yang*. Mediating K+/H+ Transport on Organelle Membranes to Selectively Eradicate Cancer Stem Cells by a Small Molecule. J. Am. Chem. Soc. 2020, 142,10769−10779.
S. Ye, N. Hananya, O. Green, H.-S. Chen, A. Q. Zhao, J.-G. Shen, D. Shabat*, D. Yang*. A Highly Selective and Sensitive Chemiluminescent Probe for Real‐Time Monitoring of Hydrogen Peroxide in Cells and Animals. Angew. Chem. Int. Ed. 2020, 59, 14326–14330.
X.-Y. Bai, K. K.-H. Ng, J. J. Hu, S. Ye, D. Yang*. Small Molecule-based Fluorescent Sensors for Selective Detection of Reactive Oxygen Species in Biological Systems. Annu. Rev. Biochem. 2019, 88, 605–633.
S. Ye, J. J. Hu, D. Yang*. Tandem Payne/Dakin Reaction: A New Strategy for Hydrogen Peroxide Detectionand Molecular Imaging. Angew. Chem. Int. Ed. 2018, 57, 10173–10177.
Molecular probes for detection and imaging of reactive oxygen species, cardiolipin, Abeta plaques, protein nitration and amination, and super-resolution imaging.
