Akio Ojida
Kyushu University
Professor
Japan
PhD from Kyushu University in 1995. In 1995-1997; post-doctoral research at Prof. Mitsuhiko Shionoya’s group; In 1997–2001, Medicinal Research Laboratories, Takeda Chemical Industries; In 2001 assistant professor of Kyushu University; In 2007, lecturer of Kyoto University; In 2010, a full professor of Kyushu University.
β-Fluorovinylsulfonamide as a Highly Reactivity- and Structure-Tunable Electrophile for Covalent Targeting of Proteins. Ojida, A* et al. Journal of the American Chemical Society, in press, (2025).
A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues. Ojida, A* et al. Journal of the American Chemical Society, 147, 3080-3091 (2025).
Fluorescence-Based Detection of Fatty Acid β Oxidation in Cells and Tissues Using Quinone Methide-Releasing Probes. Ojida, A* et al. Journal of the American Chemical Society, 145, 8248-8260 (2023).
Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins, Ojida, A* et al. Journal of the American Chemical Society, 142,43,18522-18531 (2020).
Selective and reversible modification of kinase cysteines with chlorofluoroacetamides, Ojida, A* et al. Nature Chemical Biology, 15, 250–258 (2019).
Our research focuesed on covalent drug reseach based on chemical biology approch. We design and synthesis cocalent ligands and evaluate their biochemical functions by ABPP, chemical proteomics, and WST assays, etc. Another important project in our research is the development of fluorescent probes that can detect metabolic actitivty of the cells and their application to cel bioimaging.
