Hyun-Suk Lim
POSTECH
Professor
South Korea
B.S., 1991, Hanyang University; Ph.D., 2004, POSTECH (advisor: Sung-Kee Chung); Postdoctoral Training, 2005-2008, University of Texas Southwestern Medical Center (advisor: Thomas Kodadek); Assistant Professor, 2008-2012, Indiana University; Associate/Full Professor, 2012-present, POSTECH
In situ click chemistry screen facilitated by an on-nanoparticle DNA-encoded library. Kim, M., et al. Angew. Chem. Int. Ed., e202511606 (2025)
Encoded display of chemical libraries on nanoparticles. Lee, K. J. et al. J. Am. Chem. Soc., 147, 11727 (2025)
Targeted degradation of transcription co-activator SRC-1 via the N-degron pathway. Lee, Y. et al. Angew. Chem. Int. Ed., 59, 17548 (2020)
Targeted inhibition of the NCOA1/STAT6. Lee, Y., et al. J. Am. Chem. Soc., 139, 16056 (2017)
A chemical inhibitor of the Skp2/p300 interaction. Oh, M. et al. Angew. Chem. Int. Ed., 55, 602 (2016)
Pharmacological chaperones targeting MCL-1 and α-synuclein. Oh, M. et al. Proc. Natl. Acad. Sci. U.S.A., 111, 11007 (2014)
Innovative techniques: Drug-candidate discovery via nano-based DNA-encoded libraries Translational scope: From basic chemical biology through the preclinical–clinical continuum—end-to-end drug discovery from hit identification to targeted protein degradation (PROTACs/next-generation degraders)
