Huan Wang
Nanjing University
Professor
China
Huan Wang received his Ph.D. from the University of Maryland at College Park (USA) in 2010, where he works on the chemical modification of nucleic acids. He then moved to the group of Prof. Wilfred van der Donk at the University of Illinois at Champaign-Urbana (USA) as a postdoctoral researcher, where he worked on biosynthesis of peptide natural products. In 2014, he started his independent research at Nanjing University (China), focusing on the chemical synthesis and biosynthesis of functional cyclic peptides.
α-Ketoglutarate-Dependent Dioxygenase-Catalyzed Macrocyclization in RiPPs, J. Am. Chem. Soc. 2025, 147, 26693–26703.
A Unique Class of Cyclases with a Kinase Fold Catalyzes Enethiol-mediated Macrocyclization of Aminovinyl-Cysteine Motifs in Lanthipeptides, ACS Cent. Sci. 2025, 11, 7, 1178–1188.
Phosphorescent Iridium(III) Phenanthrolinedione Complexes as Lifetime-Responsive Bioorthogonal Probes for Wash-Free Time-Resolved Bioimaging of Cellular Labeling, Angew. Chem. Int. Ed. 2025, 64, 27, e202504230.
siRNA-AGO2 complex inhibits bacterial gene translation: A promising therapeutic strategy for superbug infection, Cell Rep. Med. 2025, 6(3), 101997.
Discovery and biosynthesis of tricyclic copper-binding ribosomal peptides containing histidine-to-butyrine crosslinks, Nat. Commun. 2023, 14(1), 2944.
Discovery of a Unique Structural Motif in Lanthipeptide Synthetases for Substrate Binding and Interdomain Interactions, Angew. Chem. Int. Ed. 2022, 61, e202211382.
P(III)-Directed Late-Stage Ligation and Macrocyclization of Peptides with Olefins by Rhodium Catalysis, Angew. Chem. Int. Ed. 2022, 61, e202206177.
Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases, Nat. Chem. Biol. 2022, 18, 724-732.
Our lab operates at the dynamic crossroads of organic chemistry, enzyme chemistry, synthetic biology, and chemical biology. We are dedicated to addressing fundamental biological questions and developing innovative biotechnological solutions by harnessing the power of chemical synthesis to manipulate and understand biological systems.
