Masaki Kita
Nagoya University
Professor
Japan
Chemical biology, Natural products chemistry, Bioorganic chemistry
M.S., 2000, Nagoya University; Ph.D., 2005, Nagoya University (advisor: Daisuke Uemura); Assistant Professor, 2001-2007, Nagoya University; Assistant Professor, 2007-2011, University of Tsukuba; Associate Professor, 2011-2017, University of Tsukuba; Researcher, 2015-2018, JST–PRESTO; Professor, 2017-present, Nagoya University
Hyperpolarization Modulation of the T-type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects. Fukuoka, R., et al. Angew. Chem. Int. Ed. 64, e202503891 (2025).
Inhibition of Lysosomal Cathepsin A and Neuraminidase 1 Interaction by Anti-obesity Cyclic Peptide. Sun, Y. et al. Chem. Eur. J. 30, e202402049 (2024).
N,N-Dimethylaminopyrene as a fluorescent affinity mass tag for ligand-binding mode analysis. Arai, A. et al., Sci. Rep. 10, 7311 (2020).
Total synthesis of mycalolides A and B through olefin metathesis. Kita, M. et al., Angew. Chem. Int. Ed. 54, 14174–14178 (2015).
Aplysiasecosterol A: a 9,11-secosteroid with an unprecedented tricyclic γ-diketone structure from the sea hare Aplysia kurodai. Kawamura, A., et al. Angew. Chem. Int. Ed. 54, 7073–7076 (2015).
Marine natural products that regulate multiple cytoskeletal protein interactions. Kita, M., et al. Nat. Prod. Rep. 32, 534–542 (2015).
Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A. Kita, M., et al. J. Am. Chem. Soc. 135, 18089–18095 (2013).
Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells. Kita, M., et al. J. Am. Chem. Soc. 131, 18038–18039 (2009).
My lab can offer the investigation of the diverse natural products that regulate biologically and physiologically intriguing phenomena on the basis of bioorganic chemistry. My lab interest is also extended to chemical biology, such as study on the target molecules and mode of actions of anti-tumor and anti-obesity natural products by using their chemical probes.
