Fumi Nagatsugi
Tohoku University
Professor
Japan
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Nucleic acids chemistry, Organic chemistry, Chemical biology
B.S., 1986, Kyushu Univ.; Ph.D., 1996, Kyushu Univ. (advisor: Minoru Maeda); Postdoctoral Training, 2001-2002, National Institutes of Aging (NIA); Research Assistant, 1989-2003, Kyushu Univ.; Associate Professor, 2003-2006, Kyushu Univ.; Professor, 2006-present, Tohoku Univ.
Nagasawa, R.; Onizuka, K.; Kawamura, K.; Tsuzuki, K.; Murase, H.; Komatsu, K. R.; Miyashita, E.; Saito, H.; Kondo, J.; Nagatsugi, F. Crystallographic analysis of G-clamp-RNA complex assisted by large scale RNA-binding profile. Chemical Communications 2025, 61 (6). DOI: 10.1039/d4cc04677c.
Soemawisastra, N.; Okamura, H.; Abdelhady, A. M.; Onizuka, K.; Ozawa, M.; Nagatsugi, F. Uracil-Selective Cross-Linking in RNA and Inhibition of miRNA Function by 2-Amino-6-vinyl-7-deazapurine Deoxynucleosides. Chembiochem 2024, 25 (21). DOI: 10.1002/cbic.202400417.
Okamura, H.; Yao, T.; Nagatsugi, F. Reversible Control of Gene Expression by Guest-Modified Adenosines in a Cell-Free System via Host-Guest Interaction. Journal of the American Chemical Society 2024. DOI: 10.1021/jacs.4c04262.
Nagasawa, R.; Onizuka, K.; Komatsu, K. R.; Miyashita, E.; Murase, H.; Ojima, K.; Ishikawa, S.; Ozawa, M.; Saito, H.; Nagatsugi, F. Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries. Communications Chemistry 2024, 7 (1). DOI: 10.1038/s42004-024-01181-8.
Chen, Y. T.; Onizuka, K.; Nagatsugi, F. Michael addition-activated alkylation of G-quadruplex DNA with methylamine-protected vinyl-quinazolinone derivatives. Bioorganic & Medicinal Chemistry Letters 2024, 109. DOI: 10.1016/j.bmcl.2024.129855.
Chen, Y. T.; Onizuka, K.; Hazemi, M. E.; Nagatsugi, F. Reactivity Modulation of Reactive OFF-ON Type G-Quadruplex Alkylating Agents. Bioconjugate Chemistry 2022, 33 (11), 2097-2102. DOI: 10.1021/acs.bioconjchem.2c00458
Onizuka, K.; Ganbold, E.; Ma, Y.; Sasaki, S.; Hazemi, M. E.; Chen, Y. T.; Sato, N.; Ozawa, M.; Nagasawa, K.; Nagatsugi, F. Selective alkylation of parallel G-quadruplex structure. Organic & Biomolecular Chemistry 2021, 19 (13). DOI: 10.1039/d0ob02365e.
Abdelhady, A. M.; Onizuka, K.; Ishida, K.; Yajima, S.; Mano, E.; Nagatsugi, F. Rapid Alkene-Alkene Photo-Cross-Linking on the Base-Flipping-Out Field in Duplex DNA. J. Org. Chem. 2022, 87, 2267−2276. DOI: 10.1021/acs.joc.1c01498."
Our laboratory is dedicated to developing innovative chemical tools for controlling and elucidating gene expression within living cells. Possessing advanced expertise in organic synthesis and nucleic acid chemistry (DNA/RNA), we specialise in the design and synthesis of functional molecules for RNA-targeted drug discovery (e.g., antisense, miRNA). In particular, we are advancing the development of site-specific chemical modification techniques for nucleic acids. Our research encompasses the creation of novel supramolecular structures, such as rotaxane-forming oligonucleotides, and the development of selective probes for higher-order structures like G-quadruplexes. We guide students through the entire process, from the design and synthesis of organic compounds to biological functional evaluation, supporting them in building internationally competitive careers.
