Dehua Yang
Shanghai Institute of Materia Medica, CAS
Professor
China
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GPCRs, GLP-1R, High-throughput screening, Signal transduction, Receptor pharmacology
B.S., 2002, Yantai Normal University; Ph.D., 2009, Shanghai Institutes for Biological Sciences, CAS (advisor: Weidong Le); Postdoctoral Training, 2010-2012, Shanghai Jiao Tong University School of Medicine (advisor: Weidong Le); Assistant Professor, 2012, Shanghai Institute of Materia Medica, CAS; Associate Professor, 2012-2017, Shanghai Institute of Materia Medica, CAS; Professor, 2017-present, Shanghai Institute of Materia Medica, CAS
Dimerization and antidepressant recognition at noradrenaline transporter. Zhang, H., et al. Nature., 630(8015), 247-254 (2024)
GPCR activation and GRK2 assembly by a biased intracellular agonist. Duan, J., et al. Nature., 620(7974), 676-681 (2023)
Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Li, W., et al. Cell Discov., 10(1), 77 (2024)
Relief of loperamide-induced constipation by peptidic and small molecule RXFP4 agonists in mice. Yan, S., et al. Biochem Pharmacol. 237, 116924 (2025)
Molecular basis of signal transduction mediated by the human GIPR splice variants. Zhao, F., et al. Proc Natl Acad Sci U S A. 120(41), e2306145120 (2023)
Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24. Cong, Z., et al. Proc Natl Acad Sci U S A. 119(20), e2200155119 (2022)
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Zhao, F., Nat Commun. 13(1), 1057 (2022)
Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling. Lei, S., Eur J Pharmacol. 968, 176419 (2024)
High-throughput screening assay and facility, Compound resouces, GPCR pharmacological detection and Cryo-EM structure for key GPCRs.
